Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?
Identifieur interne : 004278 ( Main/Exploration ); précédent : 004277; suivant : 004279Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?
Auteurs : T. Tsuda ; R. Lopez [États-Unis] ; E. A. Rogaeva [Russie] ; M. Freedman [Canada] ; E. Rogaev [Russie] ; D. Drachman ; D. Pollen ; J. Haines [États-Unis] ; Y. Liang ; D. R. Crapper Mclachlan ; R. Duara [États-Unis] ; P. St George-Hyslop [Canada]Source :
- Annals of Neurology [ 0364-5134 ] ; 1994-07.
Abstract
Allele frequencies for polymorphisms in the aplipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with lateonset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late‐onset Alzheimer's disease and the ε4 (112Cys→Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with ε4 is probably not due to linkage disequilibrium.
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DOI: 10.1002/ana.410360118
Affiliations:
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A significant association was observed between late‐onset Alzheimer's disease and the ε4 (112Cys→Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with ε4 is probably not due to linkage disequilibrium.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Russie</li><li>États-Unis</li></country><region><li>Floride</li><li>Massachusetts</li><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Drachman, D" sort="Drachman, D" uniqKey="Drachman D" first="D." last="Drachman">D. Drachman</name><name sortKey="Liang, Y" sort="Liang, Y" uniqKey="Liang Y" first="Y." last="Liang">Y. Liang</name><name sortKey="Mclachlan, D R Crapper" sort="Mclachlan, D R Crapper" uniqKey="Mclachlan D" first="D. R. Crapper" last="Mclachlan">D. R. Crapper Mclachlan</name><name sortKey="Pollen, D" sort="Pollen, D" uniqKey="Pollen D" first="D." last="Pollen">D. Pollen</name><name sortKey="Tsuda, T" sort="Tsuda, T" uniqKey="Tsuda T" first="T." last="Tsuda">T. Tsuda</name></noCountry><country name="États-Unis"><region name="Floride"><name sortKey="Lopez, R" sort="Lopez, R" uniqKey="Lopez R" first="R." last="Lopez">R. Lopez</name></region><name sortKey="Duara, R" sort="Duara, R" uniqKey="Duara R" first="R." last="Duara">R. Duara</name><name sortKey="Haines, J" sort="Haines, J" uniqKey="Haines J" first="J." last="Haines">J. Haines</name></country><country name="Russie"><noRegion><name sortKey="Rogaeva, E A" sort="Rogaeva, E A" uniqKey="Rogaeva E" first="E. A." last="Rogaeva">E. A. Rogaeva</name></noRegion><name sortKey="Rogaev, E" sort="Rogaev, E" uniqKey="Rogaev E" first="E." last="Rogaev">E. Rogaev</name></country><country name="Canada"><region name="Ontario"><name sortKey="Freedman, M" sort="Freedman, M" uniqKey="Freedman M" first="M." last="Freedman">M. Freedman</name></region><name sortKey="St George Yslop, P" sort="St George Yslop, P" uniqKey="St George Yslop P" first="P." last="St George-Hyslop">P. St George-Hyslop</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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